Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1099)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0328770	0.1277412	0.7993966
Weighted median	23	-0.0292433	0.0602461	0.6273940
Inverse variance weighted	23	0.0132069	0.0489585	0.7873467
Simple mode	23	-0.0758785	0.1004611	0.4580780
Weighted mode	23	-0.0182545	0.0678576	0.7904271

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.39097	21	0.0328947
Inverse variance weighted	34.64254	22	0.0422071

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.00283	0.0072206	0.6990531

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010532	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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