Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1098)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1393912	0.1059376	0.2024302
Weighted median	23	-0.0412527	0.0545168	0.4492310
Inverse variance weighted	23	-0.0546731	0.0411752	0.1842385
Simple mode	23	-0.0146277	0.0935128	0.8771251
Weighted mode	23	-0.0769040	0.0670879	0.2639795

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.65323	21	0.3101621
Inverse variance weighted	24.50343	22	0.3214048

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0052026	0.0059881	0.3947719

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000802	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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