Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1096)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1385165	0.0998203	0.1797908
Weighted median	23	0.0381459	0.0564442	0.4991575
Inverse variance weighted	23	0.0174941	0.0390157	0.6538743
Simple mode	23	0.0485839	0.0914121	0.6004106
Weighted mode	23	0.0280296	0.0613917	0.6524557

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.85326	21	0.8758193
Inverse variance weighted	15.58824	22	0.8357830

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.007432	0.0056423	0.2019693

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004785	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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