Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1095)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0584178	0.1098031	0.6002936
Weighted median	23	-0.0023211	0.0598382	0.9690576
Inverse variance weighted	23	0.0101632	0.0421576	0.8094961
Simple mode	23	-0.0142495	0.0962305	0.8836313
Weighted mode	23	-0.0100140	0.0761276	0.8965414

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.41065	21	0.2298169
Inverse variance weighted	25.68648	22	0.2653861

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0029633	0.0062066	0.6379766

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007804	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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