Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1094)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0741506	0.1207256	0.5456754
Weighted median	23	-0.0732813	0.0627688	0.2430166
Inverse variance weighted	23	-0.0264186	0.0463038	0.5683057
Simple mode	23	-0.1590532	0.1396770	0.2670676
Weighted mode	23	-0.1693160	0.1148053	0.1544316

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.71829	21	0.0784758
Inverse variance weighted	30.98819	22	0.0963575

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0029312	0.006824	0.6719009

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009529	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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