Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1093)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1049117	0.1229909	0.4032821
Weighted median	23	0.0062373	0.0607474	0.9182199
Inverse variance weighted	23	0.0197504	0.0483038	0.6826289
Simple mode	23	0.0177046	0.1090430	0.8725016
Weighted mode	23	-0.0054927	0.0641472	0.9325374

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.88157	21	0.0601861
Inverse variance weighted	33.72252	22	0.0524078

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0076555	0.0069521	0.2832779

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010296	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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