Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1092)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1259929	0.1055654	0.2459807
Weighted median	23	0.0329852	0.0622888	0.5964221
Inverse variance weighted	23	0.0080010	0.0420982	0.8492649
Simple mode	23	0.0707091	0.1173055	0.5528207
Weighted mode	23	0.0423358	0.0870088	0.6313758

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.48752	21	0.3185457
Inverse variance weighted	25.61441	22	0.2686051

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0082286	0.0059671	0.1824076

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007775	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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