Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1091)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1622541	0.0998182	0.1189712
Weighted median	23	0.1015844	0.0567354	0.0733745
Inverse variance weighted	23	0.0800887	0.0390150	0.0400955
Simple mode	23	0.0958387	0.1054309	0.3731916
Weighted mode	23	0.1369957	0.0648292	0.0461612

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.04243	21	0.5185748
Inverse variance weighted	20.84219	22	0.5305084

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0050458	0.0056423	0.3813008

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007592	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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