Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1090)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0418129	0.1227549	0.7367729
Weighted median	23	-0.0338166	0.0553702	0.5413744
Inverse variance weighted	23	-0.0292567	0.0468901	0.5326649
Simple mode	23	-0.0799062	0.0905683	0.3871667
Weighted mode	23	-0.0473618	0.0570372	0.4152528

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.75815	21	0.0619330
Inverse variance weighted	31.77683	22	0.0812812

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0007711	0.0069387	0.9125714

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009799	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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