Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 109)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0027355	0.1193647	0.9819327
Weighted median	23	0.0703652	0.0553630	0.2037365
Inverse variance weighted	23	0.0425472	0.0457242	0.3521022
Simple mode	23	0.0503352	0.0974768	0.6107396
Weighted mode	23	0.0503352	0.0591373	0.4038506

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.02850	21	0.0914169
Inverse variance weighted	30.21625	22	0.1133025

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0024448	0.006747	0.7207078

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009517	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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