Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1089)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1596575	0.0999132	0.1249901
Weighted median	23	0.0602896	0.0561830	0.2832296
Inverse variance weighted	23	0.0270098	0.0399994	0.4995134
Simple mode	23	0.0543159	0.0966834	0.5799372
Weighted mode	23	0.0740723	0.0723422	0.3170032

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.03942	21	0.4565393
Inverse variance weighted	23.12375	22	0.3947702

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0081459	0.0056476	0.1639478

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007152	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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