Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1088)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0528482	0.1110230	0.6389810
Weighted median	23	0.0248898	0.0546168	0.6485936
Inverse variance weighted	23	0.0643985	0.0424095	0.1288900
Simple mode	23	0.0821342	0.0824431	0.3299595
Weighted mode	23	0.0429087	0.0596501	0.4795034

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.97784	21	0.2072952
Inverse variance weighted	25.99364	22	0.2519550

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0007093	0.0062755	0.9110832

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008702	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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