Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1087)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0429037	0.1246154	0.7340528
Weighted median	23	-0.0096871	0.0602398	0.8722438
Inverse variance weighted	23	-0.0462619	0.0482672	0.3378334
Simple mode	23	-0.0052711	0.1041300	0.9600850
Weighted mode	23	0.0084875	0.0744587	0.9102804

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.72898	21	0.0493101
Inverse variance weighted	33.67079	22	0.0530408

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0054757	0.0070439	0.4456124

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010629	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8