Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1086)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0085652	0.1187103	0.9431639
Weighted median	23	-0.0688994	0.0597939	0.2492052
Inverse variance weighted	23	-0.0501244	0.0456422	0.2721156
Simple mode	23	-0.1517628	0.1119049	0.1887998
Weighted mode	23	-0.1141498	0.0798372	0.1668283

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.70044	21	0.0981749
Inverse variance weighted	30.10847	22	0.1158518

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0036041	0.0067101	0.5968302

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009623	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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