Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1085)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1782700	0.1061733	0.1079620
Weighted median	23	0.0504647	0.0611371	0.4091246
Inverse variance weighted	23	0.0113673	0.0432684	0.7927702
Simple mode	23	0.0259777	0.1141838	0.8221299
Weighted mode	23	0.0620701	0.0720503	0.3982649

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.75825	21	0.3049191
Inverse variance weighted	27.05806	22	0.2090297

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0102495	0.0060014	0.1024087

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008225	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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