Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1084)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0227523	0.1057290	0.8316918
Weighted median	23	0.0020311	0.0546594	0.9703574
Inverse variance weighted	23	-0.0147486	0.0405173	0.7158528
Simple mode	23	0.0562023	0.0968507	0.5676104
Weighted mode	23	0.0056043	0.0604681	0.9269945

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.55944	21	0.3148907
Inverse variance weighted	23.72602	22	0.3617529

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0023029	0.0059763	0.7038597

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007233	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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