Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1083)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1330937	0.1179874	0.2720293
Weighted median	23	0.0915604	0.0556715	0.1000408
Inverse variance weighted	23	0.0080311	0.0464565	0.8627515
Simple mode	23	0.0977030	0.0916014	0.2977131
Weighted mode	23	0.1012115	0.0639745	0.1279069

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.33957	21	0.1060848
Inverse variance weighted	31.19231	22	0.0922469

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0076801	0.0066692	0.2624401

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009464	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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