Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1082)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0806606	0.0998204	0.4281167
Weighted median	23	0.0269054	0.0554454	0.6274928
Inverse variance weighted	23	0.0099752	0.0390157	0.7982037
Simple mode	23	0.0216494	0.0866954	0.8051222
Weighted mode	23	0.0345311	0.0664494	0.6084899

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.39431	21	0.4964231
Inverse variance weighted	20.98617	22	0.5215932

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0043408	0.0056423	0.4502675

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006379	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8