Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1081)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0720164	0.1054198	0.5019868
Weighted median	23	-0.0583079	0.0569986	0.3063212
Inverse variance weighted	23	-0.0612420	0.0402686	0.1283009
Simple mode	23	-0.0862043	0.0982584	0.3897917
Weighted mode	23	-0.0401492	0.0701082	0.5726723

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.42210	21	0.3218921
Inverse variance weighted	23.43586	22	0.3774787

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0006617	0.0059589	0.9126404

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007848	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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