Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1080)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0731953	0.1187028	0.5441086
Weighted median	23	0.0667867	0.0550195	0.2247965
Inverse variance weighted	23	0.0283888	0.0455104	0.5327668
Simple mode	23	0.0260781	0.0958314	0.7880641
Weighted mode	23	0.0664894	0.0599318	0.2792308

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.69692	21	0.0982497
Inverse variance weighted	29.93474	22	0.1200592

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0027516	0.0067096	0.6858934

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009231	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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