Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 108)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0350170	0.1148403	0.7634291
Weighted median	23	0.0341624	0.0611220	0.5762156
Inverse variance weighted	23	-0.0008356	0.0439741	0.9848395
Simple mode	23	-0.0845181	0.1209606	0.4920452
Weighted mode	23	0.0208233	0.0784525	0.7931528

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.79570	21	0.1460413
Inverse variance weighted	27.94797	22	0.1774121

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0022017	0.0064913	0.7378451

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008469	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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