Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1079)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0337911	0.1249001	0.7893820
Weighted median	23	-0.0791665	0.0624297	0.2047661
Inverse variance weighted	23	-0.0371204	0.0476965	0.4364144
Simple mode	23	-0.1483330	0.0977854	0.1435249
Weighted mode	23	-0.1030703	0.0719117	0.1658345

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.87861	21	0.0475806
Inverse variance weighted	32.87992	22	0.0635831

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0002045	0.00706	0.9771706

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010237	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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