Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1078)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1043393	0.0998195	0.3077775
Weighted median	23	0.0103460	0.0593288	0.8615631
Inverse variance weighted	23	0.0275025	0.0390154	0.4808644
Simple mode	23	0.0224751	0.1049124	0.8323432
Weighted mode	23	0.0309547	0.0766707	0.6903047

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.58720	21	0.4843882
Inverse variance weighted	21.28657	22	0.5030930

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0047186	0.0056423	0.412411

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006601	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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