Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1077)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2040032	0.0998170	0.0537210
Weighted median	23	-0.0145337	0.0597106	0.8076941
Inverse variance weighted	23	0.0278265	0.0391433	0.4771535
Simple mode	23	0.0034606	0.1053254	0.9740855
Weighted mode	23	-0.0155295	0.1076159	0.8865737

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.46821	21	0.6192123
Inverse variance weighted	22.14517	22	0.4512528

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0108192	0.0056422	0.0688726

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006864	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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