Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1076)

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 0.0912013 0.1018766 0.3808196
Weighted median 23 -0.0136898 0.0574415 0.8116286
Inverse variance weighted 23 -0.0093781 0.0399552 0.8144304
Simple mode 23 -0.0474530 0.0914025 0.6088294
Weighted mode 23 -0.0129509 0.0633167 0.8398111

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 21.87403 21 0.4068001
Inverse variance weighted 23.07236 22 0.3976533

Test for directional horizontal pleiotropy

egger_intercept se pval
-0.0061765 0.0057585 0.2956267

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0007009 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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