Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1075)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0738832	0.1073837	0.4989639
Weighted median	23	0.1318850	0.0559516	0.0184170
Inverse variance weighted	23	0.0854086	0.0410203	0.0373329
Simple mode	23	-0.0009747	0.1035830	0.9925770
Weighted mode	23	0.1125395	0.0721076	0.1328615

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.30389	21	0.2785683
Inverse variance weighted	24.31963	22	0.3307010

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0007078	0.0060699	0.9082813

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008821	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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