Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1073)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0398356	0.0998200	0.6938680
Weighted median	23	0.0995671	0.0578570	0.0852660
Inverse variance weighted	23	0.0541729	0.0390154	0.1649843
Simple mode	23	0.0355531	0.1053223	0.7388912
Weighted mode	23	0.1119107	0.0851170	0.2021233

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.27040	21	0.7542710
Inverse variance weighted	16.29475	22	0.8009927

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0008805	0.0056423	0.8774878

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005522	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8