Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1072)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0616164	0.1002364	0.5453492
Weighted median	23	0.0269068	0.0548138	0.6235147
Inverse variance weighted	23	0.0176851	0.0390155	0.6503446
Simple mode	23	-0.0171514	0.0902449	0.8510096
Weighted mode	23	0.0131822	0.0608952	0.8306137

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.17532	21	0.4482830
Inverse variance weighted	21.40393	22	0.4959087

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0026978	0.0056658	0.6388808

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006548	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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