Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1071)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1517008	0.1013392	0.1492833
Weighted median	23	-0.0381116	0.0559011	0.4953858
Inverse variance weighted	23	-0.0162218	0.0405957	0.6894553
Simple mode	23	-0.0579552	0.0849812	0.5023715
Weighted mode	23	-0.0277152	0.0602776	0.6501773

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.64393	21	0.4202717
Inverse variance weighted	23.81815	22	0.3568333

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0083198	0.0057282	0.1611621

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000727	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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