Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1070)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0703910	0.1028422	0.5011720
Weighted median	23	-0.0326230	0.0569680	0.5668783
Inverse variance weighted	23	-0.0322013	0.0394247	0.4140545
Simple mode	23	0.0050525	0.0948801	0.9580121
Weighted mode	23	-0.0009270	0.0759862	0.9903759

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.29095	21	0.3829129
Inverse variance weighted	22.46372	22	0.4325193

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0023452	0.0058131	0.6907061

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007014	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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