Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 107)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0062106	0.0998200	0.9509778
Weighted median	23	-0.0244855	0.0576030	0.6707828
Inverse variance weighted	23	-0.0114824	0.0390155	0.7685268
Simple mode	23	0.0896802	0.1063398	0.4081168
Weighted mode	23	-0.0316197	0.0825272	0.7052910

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.85811	21	0.7775697
Inverse variance weighted	15.89519	22	0.8210532

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0010865	0.0056423	0.8491481

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004843	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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