Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1069)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0118188	0.1112201	0.9163809
Weighted median	23	0.0247763	0.0597218	0.6782433
Inverse variance weighted	23	0.0150192	0.0424726	0.7236238
Simple mode	23	0.0175133	0.0911209	0.8493494
Weighted mode	23	0.0400012	0.0688523	0.5671651

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.07043	21	0.2037762
Inverse variance weighted	26.07165	22	0.2486186

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0001965	0.0062867	0.9753557

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007945	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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