Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1068)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0693791	0.1025887	0.5062411
Weighted median	23	0.0189793	0.0562690	0.7358942
Inverse variance weighted	23	-0.0140711	0.0394948	0.7216332
Simple mode	23	0.0494936	0.0992293	0.6228852
Weighted mode	23	0.0494936	0.0729258	0.5044157

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.18163	21	0.3891085
Inverse variance weighted	22.54400	22	0.4278479

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0033965	0.0057988	0.5643073

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000687	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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