Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1067)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1427434	0.0998195	0.1674233
Weighted median	23	0.0880864	0.0546242	0.1068336
Inverse variance weighted	23	0.0623406	0.0390154	0.1100774
Simple mode	23	0.1029487	0.0914858	0.2725904
Weighted mode	23	0.0812702	0.0639992	0.2174014

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.81202	21	0.7224365
Inverse variance weighted	17.57781	22	0.7307059

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0049376	0.0056423	0.3914211

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.00061	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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