Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1066)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0817866	0.1327264	0.5443818
Weighted median	23	-0.0156621	0.0553942	0.7773774
Inverse variance weighted	23	0.0536736	0.0521469	0.3033496
Simple mode	23	-0.0423883	0.0930057	0.6530295
Weighted mode	23	-0.0034353	0.0577849	0.9531304

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	37.12763	21	0.0162749
Inverse variance weighted	39.30126	22	0.0130309

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0083185	0.0075022	0.2800535

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012482	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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