Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1065)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1237578	0.0998198	0.2287213
Weighted median	23	0.0109477	0.0527047	0.8354497
Inverse variance weighted	23	-0.0354909	0.0390155	0.3630020
Simple mode	23	0.0121198	0.0808016	0.8821358
Weighted mode	23	0.0149791	0.0610740	0.8085274

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.65897	21	0.7315599
Inverse variance weighted	19.66309	22	0.6041050

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0097794	0.0056423	0.0977136

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006209	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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