Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1064)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0209006	0.1026843	0.8406705
Weighted median	23	-0.0076677	0.0539494	0.8869788
Inverse variance weighted	23	-0.0170766	0.0392139	0.6632197
Simple mode	23	0.0013785	0.0799552	0.9863998
Weighted mode	23	-0.0209062	0.0635768	0.7453905

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.22245	21	0.3867895
Inverse variance weighted	22.22418	22	0.4465777

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0002348	0.0058042	0.9681092

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006792	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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