Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1063)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0314466	0.1059637	0.7695593
Weighted median	23	-0.0078876	0.0574463	0.8907901
Inverse variance weighted	23	-0.0059620	0.0405304	0.8830535
Simple mode	23	-0.0697164	0.1012842	0.4984427
Weighted mode	23	-0.0397601	0.0641020	0.5414571

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.66472	21	0.3095856
Inverse variance weighted	23.74166	22	0.3609156

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.001565	0.0059896	0.7964156

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007201	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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