Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1062)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0306296	0.1131554	0.7892752
Weighted median	23	0.0005189	0.0549128	0.9924602
Inverse variance weighted	23	-0.0283841	0.0435399	0.5144587
Simple mode	23	-0.0625777	0.1039110	0.5531820
Weighted mode	23	0.0376926	0.0637522	0.5603887

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.98544	21	0.1713355
Inverse variance weighted	27.39798	22	0.1964992

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.003624	0.0063961	0.5769919

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008462	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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