Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1061)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1539400	0.0998209	0.1379697
Weighted median	23	0.0051345	0.0514738	0.9205436
Inverse variance weighted	23	0.0017929	0.0390158	0.9633482
Simple mode	23	0.0167930	0.0871962	0.8490474
Weighted mode	23	0.0300724	0.0664144	0.6551269

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	9.880304	21	0.9804244
Inverse variance weighted	12.622402	22	0.9431604

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0093433	0.0056424	0.1126043

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003826	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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