Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1060)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0077396	0.0998212	0.9389319
Weighted median	23	0.0069338	0.0522960	0.8945189
Inverse variance weighted	23	0.0007907	0.0390157	0.9838302
Simple mode	23	0.0183695	0.0853561	0.8315858
Weighted mode	23	0.0117432	0.0639688	0.8560266

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	10.09471	21	0.9776559
Inverse variance weighted	10.10043	22	0.9853711

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0004267	0.0056424	0.9404296

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003061	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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