Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 106)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1589644	0.1122303	0.1713181
Weighted median	23	0.1341888	0.0569767	0.0185152
Inverse variance weighted	23	0.0997944	0.0431910	0.0208584
Simple mode	23	0.2045861	0.0973087	0.0471824
Weighted mode	23	0.1580706	0.0655264	0.0246340

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.54665	21	0.1863673
Inverse variance weighted	26.96139	22	0.2126966

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0036337	0.0063438	0.5728732

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010152	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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