Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1059)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1586179	0.1095858	0.1625408
Weighted median	23	-0.0783011	0.0568357	0.1683038
Inverse variance weighted	23	-0.0469215	0.0430524	0.2757709
Simple mode	23	-0.1122527	0.1086776	0.3128739
Weighted mode	23	-0.1055850	0.0642437	0.1144944

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.31081	21	0.2339538
Inverse variance weighted	26.78875	22	0.2193602

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0068593	0.0061943	0.2806658

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008556	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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