Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1058)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0708718	0.1288278	0.5880356
Weighted median	23	-0.0449943	0.0577472	0.4358858
Inverse variance weighted	23	-0.0350809	0.0501219	0.4839832
Simple mode	23	-0.0198240	0.1033807	0.8496913
Weighted mode	23	-0.0713461	0.0740405	0.3457152

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.97924	21	0.0283836
Inverse variance weighted	36.30906	22	0.0281286

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0065065	0.007282	0.3817078

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011247	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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