Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1057)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0292202	0.1083551	0.7900456
Weighted median	23	-0.0428610	0.0549209	0.4351473
Inverse variance weighted	23	0.0007255	0.0414581	0.9860385
Simple mode	23	-0.0790534	0.0886346	0.3820975
Weighted mode	23	-0.0595731	0.0617124	0.3448697

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.74440	21	0.2584041
Inverse variance weighted	24.84058	22	0.3047592

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0017499	0.0061247	0.7779048

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007527	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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