Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1056)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1106702	0.0998195	0.2800945
Weighted median	23	-0.0115888	0.0562025	0.8366362
Inverse variance weighted	23	0.0163398	0.0390154	0.6753597
Simple mode	23	0.0085489	0.0966101	0.9302889
Weighted mode	23	-0.0042342	0.0720680	0.9536798

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.14345	21	0.5759384
Inverse variance weighted	20.19753	22	0.5706855

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0057929	0.0056423	0.3162514

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006173	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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