Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1055)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1074079	0.1206154	0.3832869
Weighted median	23	0.0954220	0.0604436	0.1144059
Inverse variance weighted	23	0.0390969	0.0464729	0.4001895
Simple mode	23	0.0897611	0.1080575	0.4150796
Weighted mode	23	0.0931190	0.0849667	0.2849546

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.66174	21	0.0794748
Inverse variance weighted	31.21452	22	0.0918088

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.004195	0.0068178	0.5449673

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009763	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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