Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1054)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0065989	0.1088852	0.9522476
Weighted median	23	-0.0328126	0.0575424	0.5685196
Inverse variance weighted	23	-0.0422188	0.0417049	0.3113830
Simple mode	23	-0.1020821	0.0859279	0.2475022
Weighted mode	23	-0.0478241	0.0620463	0.4490361

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.9871	21	0.2477231
Inverse variance weighted	25.1374	22	0.2905494

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0021874	0.0061547	0.7258311

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007972	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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