Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1053)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0147929	0.1208689	0.9037554
Weighted median	23	-0.0142118	0.0605035	0.8142928
Inverse variance weighted	23	-0.0097867	0.0462103	0.8322731
Simple mode	23	0.1017204	0.1150486	0.3861753
Weighted mode	23	-0.0429840	0.0780348	0.5873004

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.79111	21	0.0772054
Inverse variance weighted	30.86268	22	0.0989599

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0015094	0.0068321	0.8272784

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009371	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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