Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1052)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1089041	0.0998207	0.2876339
Weighted median	23	-0.0338478	0.0581614	0.5605915
Inverse variance weighted	23	-0.0402422	0.0390155	0.3023339
Simple mode	23	-0.1668927	0.1039685	0.1227048
Weighted mode	23	0.0023856	0.0702397	0.9732121

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.49557	21	0.6806638
Inverse variance weighted	20.13058	22	0.5748722

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.009159	0.0056423	0.1194486

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006422	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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